January 2009

Prostate cancer Q&A

1.30.2009 Jen Smith
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Radiation oncologist Richard K. Valicenti, MD, is associate professor and clinical chief of Radiation Oncology, Thomas Jefferson Medical College, and co-director of Genitourinary Oncology Center, Thomas Jefferson University Hospital. Here, he answers a patient’s question about the use of robots in treating prostate cancer.

Question: I’ve heard that doctors are using robots to treat prostate cancer. Is that possible?

Answer: It’s not only possible, it’s absolutely true, and at Jefferson, use of this state-of-the-art technology places our doctors at the forefront of prostate cancer treatment. When you consider that prostate cancer is the number one cause of cancer in men and one of the leading causes of cancer death in men, clearly this new robotic technology is invaluable.

The robotic seed implant has advanced the way that Jefferson doctors perform the radioactive seed implant, a common treatment mode for prostate cancer. With radioactive seed implant – a minimally invasive, localized therapy performed under general anesthesia – tiny needles are used to place small, radioactive pellets, or “seeds” about the size of a grain of rice, into the prostate. The seeds, which are so small they don’t cause any discomfort, deliver radiation from inside the gland for a number of months. Previously, the implant was done manually.

Kick start your heart health at the King of Prussia Mall

1.27.2009 Jen Smith
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Join us for this special day of fun and education!

Saturday, February 28, 2009
11 a.m. to 2 p.m.
King of Prussia Mall, Lord & Taylor Court

  • Learn how to make your tailgate “heart healthy” at our cooking demonstration, featuring our area’s best chefs.
  • Meet the Heartbeat of our Team – Philadelphia Eagles Kicker, David Akers.
  • Test your fitness level with Wii Fit.
  • Ask our Jefferson physicians your heart health questions.
  • Get your free blood pressure screening.
  • Visit our information table for free recipes and other heart healthy tips.
  • Win prizes and get free gifts.

Visit www.JeffersonHospital.org/kickheartdisease for more information.

Middle-aged men advised to follow medical guidelines

1.27.2009 Jen Smith
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The U.S. Department of Health and Human Services’ Agency for Healthcare Research and Quality (AHRQ) joined with The Advertising Council to launch a national public service campaign designed to raise awareness among middle-aged men about the importance of preventive medical testing.

Men are 25 percent less likely than women to have visited a physician within the past year – and 38 percent more likely than women to have neglected their cholesterol tests. Furthermore, men are 1.5 times more likely than women to die from heart disease, cancer and chronic lower respiratory diseases, according to the Centers for Disease Control and Prevention (CDC).

The new campaign encourages men over 40 to learn which preventive screening tests they need to get and when they need to get them. It’s intended to inform men about the importance of prevention and show them that they should work with their health care providers to find out what they should do to stay healthy.

The campaign highlights the work of the AHRQ-sponsored U.S. Preventive Services Task Force – an independent panel of experts in primary care and prevention that reviews the evidence of effectiveness and develops recommendations for clinical preventive services.

Research conducted during the development of the campaign found that despite their increased health risks, men aren’t taking preventive steps and are often only visiting their doctors when they experience symptoms.

New treatments halt development of esophageal cancer

1.23.2009 Jen Smith
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Esophageal cancer – a consequence of Barrett’s esophagus – is among the fastest-growing cancers in the United States. Barrett’s esophagus is a condition in which the cells on the lining of the esophagus (the tube that carries foods and liquids from the mouth to the stomach) change and, in time, may become cancerous. It results from prolonged gastroesophageal reflux disease (GERD) – which is common among U.S. adults.

Before the introduction of photodynamic therapy (PDT), high-risk surgery was the only option to fix Barrett’s esophagus. PDT uses a light-sensitive chemical injected into the body and activated by a laser light to target the cells.

Experts at Thomas Jefferson University Hospital now use novel techniques – such as freezing or radiofrequency ablation (referred to as the HALO procedure) to potentially fix Barrett’s esophagus with fewer side effects.

BARRX HALO technology enables physicians to use a viewing scope, guide wire and balloon to map and measure the damaged area. A second balloon wrapped with hair-like wires is then slipped down the esophagus and inflated. Bursts of radiofrequency energy are sent along the wire to destroy the potentially precancerous cells.

Lose weight the healthy way

1.21.2009 Jen Smith
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As we enter the New Year, many of us have made resolutions – including the goal to slim down. If losing weight is on your 2009 to-do list, consider meeting your goal with a healthy, balanced plan instead of using fads, fasting or other popular diets.

To lose weight and keep it off for a lifetime, begin thinking about an individualized eating plan instead of a “diet.” A plan tailored to personal likes and dislikes will have a better chance of producing sustainable weight loss. Consider the following tips:

Primary insomnia better understood

1.15.2009 Jen Smith
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The most common type of insomnia is secondary insomnia, which occurs in conjunction with another illness or disorder, either physical or mental, or as a side effect of certain medications or substances. Primary insomnia occurs without a coexisting condition, persists for one month or longer and affects approximately a quarter of the adult population.

A new study suggests that a specific neurochemical imbalance found in adults with primary insomnia makes it more difficult for their brains to settle down for sleep.

Many adults suffering from insomnia complain of a “racing mind” and an inability to shut down at night. Researchers now suggest this experience is not just “in your head.” Rather, it’s a result of a decrease in the neurochemical gamma-aminobutyric acid (GABA).

As reported in the medical journal Sleep, people with primary insomnia for more than six months have 30 percent less GABA, a chemical that slows overall activity in many brain areas. According to one of the principal investigators, GABA is reduced in the brain of individuals with insomnia – suggesting overactivity is present not only at the level of excessive thoughts and emotions, but can also be detected at the level of the nervous system.

Read more about the study’s findings, and learn how Jefferson’s Sleep Disorders Center helps in diagnosing and treating a range of sleep problems.

Fatty liver disease running rampant, Jefferson expert says

1.13.2009 Jen Smith
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Fatty liver disease is running rampant in the American adult population, says Victor J. Navarro, MD, medical director of Liver Transplantation at Thomas Jefferson University Hospital.

Dr. Navarro is one of three dedicated hepatologists in Jefferson’s Liver Disease and Transplantation Program, in which Jefferson’s Division of Gastroenterology and Hepatology and Division of Transplantation Surgery in the Department of Surgery collaborate.

“High fat in the liver can cause inflammation, perhaps leading to cirrhosis, liver scarring, cancer and, ultimately, liver failure,” notes Dr. Navarro, who is also clinical associate professor of Medicine at Jefferson Medical College of Thomas Jefferson University.

“Treatment focuses on factors that seem to lead to fatty liver – including obesity and diabetes. But we’re also researching new treatments, a better understanding of the cause and a better way to identify patients at risk for fatty liver and livers disease.

Enzyme may hold the key to successfully treating pancreatic cancer

1.09.2009 Jen Smith
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An enzyme that is overexpressed in pancreatic cancer cells may hold the key to successfully treating the disease with targeted immunotherapy, researchers from Thomas Jefferson University reported at the 2008 Annual Meeting of the Southern Surgical Association.

Previous data show that a protein, indoleamine 2,3-dioxygenase (IDO), is overexpressed in pancreatic ductal adenocarcinomas, according to Jonathan R. Brody, Ph.D., an assistant professor in the Department of Surgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and co-director of the Jefferson Center for Pancreas, Biliary and Related Cancers. The center is led by Charles J. Yeo, M.D., Samuel D. Gross Professor and chair of the Department of Surgery, who was also involved with the study.

According to Dr. Brody, IDO is an enzyme that represses the immune system – protecting the cancer cells and helping them evade immune detection. The Jefferson researchers and their collaborators from the Lankenau Institute for Medical Research (LIMR) in Wynnewood, Pa., previously reported that the IDO inhibitor D-1-methyl-tryptophan (1-MT), preferentially targets a related protein, IDO2.

Changes and Challenges: Sports Medicine for Young Athletes

1.06.2009 Jen Smith
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Find out more about the sports medicine changes, challenges affecting today’s high-school athletes.

Each year, more than seven million high-school students participate in interscholastic sports in the United States – with more than 1.6 million sports injuries, according to a 2006 national sports injury survey.

Thanks to growing awareness of the importance of preventing and treating injuries, injury rates among high-school athletes have dropped. However, experts say that the injuries reported today are more serious.

As Peter DeLuca, MD, of the Rothman Institute at Jefferson, explains, many schools simply lack adequate sports medicine resources. He notes that historically, many schools have relied on a general practitioner to provide sports medicine – even though the field requires specialized training.

“Today, we are training more sports medicine physicians, both nonoperative and operative,” he says. “But there are still some communities where there’s only one trainer handling hundreds of student athletes across several highly competitive boys’ and girls’ programs.”

Indeed, national statistics suggest that, on average, secondary schools have one athletic trainer for 300 to 500 children. By contrast, a college football team typically has three or four trainers for a team of 120.
Tight schools budgets are part of the reason, but Dr. DeLuca says another is lack of awareness and understanding about injuries.

Joint Replacement Surgery: What to Expect

1.06.2009 Jen Smith
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Interactive presentation helps patients know what to expect before, during and after a joint replacement procedure at Jefferson

Joint replacement surgery can be a life-changing event. Whether you’re already scheduled for a procedure or are simply looking for more information, “Joint Replacement at Jefferson” – a new, interactive presentation – will help you learn more about what to expect.

Through six user-friendly modules, “Joint Replacement at Jefferson” walks you through how to best prepare for:

  • Registration and pre-admission testing
  • What to expect before surgery
  • Preparing for the day of surgery
  • What to expect after the surgery
  • How to best plan for discharge
  • How others can help during your recovery

The presentation also provides access to a collection of valuable resources – including detailed videos of procedures, a list of frequently asked questions and much more.

Take just a few moments to interact with “Joint Replacement at Jefferson” – and then share the link with family members or friends who are considering joint replacement surgery.

Back Pain: Are More Therapies Helping?

1.06.2009 Jen Smith
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A study suggests that spending more money to treat back and neck pain hasn’t equated to better results—but the analysis is fundamentally flawed, say two Jefferson surgeons

In June, the Journal of the American Medical Association published the results of a study suggesting that spending more money on back and neck pain from 1997 to 2005 did not actually produce more or better relief for patients.

According to the article, 26 percent of U.S. adults in 2002 reported lower back pain, and 14 percent reported neck pain during the previous three months. What’s more, low back pain accounted for about 2 percent of all visits to a physician’s office – exceeded only by routine exams, hypertension and diabetes.

The study’s authors note that rates of imaging, injections, use of opiates and surgeries related to spine pain have increased. And they set out to answer the question: Have these expenditures resulted in proportional improvements for patients?

The study’s findings
The investigators used data from the Medical Expenditure Panel Survey, which sampled individuals around the nation ages 17 and older from 1997 to 2005.

Undertreatment of women linked to more heart attack deaths

1.06.2009 Jen Smith
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Recent studies show an increase in deaths and a difference in the medical treatment given to women compared to men when suffering a severe heart attack.

More than 78,000 people treated for heart attacks at 420 U.S. hospitals between 2001 and 2006 found the same overall in-hospital death rate for men and women. However, a study reveals 10.2 percent of women with a severe form of heart attack called ST-elevation myocardial infarction, or STEMI, died – compared to 5.5 percent of men with the same diagnosis, according to an article in the medical journal Circulation.

The study found there was clearly a difference in the treatment given to men and women. For example, women were:

  • 14 percent less likely to receive early aspirin
  • 10 percent less likely to be given beta blocker medications
  • 25 percent less likely to receive reperfusion therapy to restore blood flow
  • 13 less likely to have artery-opening angioplasty within 90 minutes of arrival at the hospital

Read more about the study’s findings, and then explore Thomas Jefferson University Hospital’s capabilities in heart care.