May 2009

Jefferson Celebrates the 25th Anniversary of First Liver Transplant in Region

5.29.2009 Jen Smith
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Jefferson Hospital held a celebration earlier this month to commemorate the first liver transplant performed in the region. Twenty-five years after the procedure was performed here at Thomas Jefferson University Hospital, the recipient of the transplant remains healthy and active, as does Jefferson’s Liver Transplantation Program.

Today, Jefferson’s is not only the longest continuously active liver transplantation program in the area but also one of the fastest growing, having performed transplants in more than half the patients on our waiting list in the last three years. Jefferson has developed innovative therapies to improve the quality of life for our liver transplant patients, including new anti-rejection protocols.

In addition, Jefferson uses a bloodless technique for performing major liver resection that was co-developed by Jefferson surgeon Cataldo Doria, MD, PhD and former colleagues at the University of Pittsburgh Medical Center – Italy.

Learn more about the Liver Transplantation Program, including its multidisciplinary nature and the future launch of a Living Donor arm of our Liver Transplantation Program.

See the story about our transplantation anniversary and transplant recipient Michael Donahue on KYW-1060’s website.

Prostate Cancer: Screening Doesn’t Save Lives?

5.27.2009 Jen Smith
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According to the Prostate Cancer Foundation, prostate cancer is the most common non-skin cancer in America – affecting one in six men. This year, more than 192,000 men will be diagnosed with prostate cancer, and more than 27,000 men will die from the disease.

The most common way to screen for prostate cancer is a blood test that measures prostate specific antigen (PSA). Because various factors can lead to elevated PSA levels, a biopsy must be performed to confirm a tumor.

Two studies published this spring in the New England Journal of Medicine suggest that screening for prostate cancer doesn’t necessarily save lives – and that any benefits of screening can come at a high price.

The studies – one in the United States and the other in Europe – reached different conclusions.

In the U.S., where screening is widely used, researchers reported that it did not save lives in a study of 76,000 men. In Europe, where PSA screening isn’t a routine practice, researchers studied 162,000 men and found a slight reduction of about seven fewer deaths per 10,000 men screened. However, screening subjected men to the risk of getting treatments they didn’t need – and experiencing serious side effects, such as impotence and incontinence.

What Does it Mean for You?
When the studies were released, local TV news stations turned to Leonard Gomella, MD, chair of the Department of Urology at Thomas Jefferson University Hospital.

New Study: Caffeine and Breast Cancer Risk

5.26.2009 Jen Smith
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Study suggests caffeine consumption doesn’t increase overall breast cancer risk – but could boost risk for those with benign breast disease

Found in coffee, chocolate, tea, soft drinks and various medications, caffeine is thought to be the world’s most commonly ingested drug. There is no shortage of studies examining the connection between caffeine and medical conditions. Some find caffeine to be beneficial. Others find it harmful. And still others see little effect.

A study recently published in the Archives of Internal Medicine examined the linkage between caffeine consumption and overall breast cancer risk. The study found that drinking coffee or consuming other caffeine-laden foods does not appear to boost overall breast cancer risk.

However, the study suggests that women who consume a lot of caffeine – four or more cups of coffee daily – and have benign breast disease could be at increased risk of breast cancer. What’s more, the study authors note, there could be an increased risk of developing certain subtypes of breast tumors that have less favorable outcomes.

Caffeine and Benign Breast Problems
As noted in the current study, other recent research focused on women with benign, or non-cancerous, breast disease found that symptoms could improve when caffeine was cut from the diet. And because benign breast disease is considered to be a risk factor for developing the malignant form of the disease, this finding had raised concerns that caffeine might also elevate the risk for breast cancer.

Robotic Assisted Minimally Invasive Esophagectomy

5.26.2009 Jen Smith
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Jefferson is the first hospital in Philadelphia to offer this innovative procedure

Thomas Jefferson University Hospital is the first in the city to offer robotic esophageal mobilization surgery, using the da Vinci® Robotic System. This procedure is ideal for esophageal cancer patients who require surgery to remove all or part of their esophagus. 

It is a viable alternative to more invasive “open” surgery and will allow the patient to recover faster and leave the hospital sooner. It improves on conventional minimally invasive techniques by decreasing the number of incisions required to perform the procedure.

“It’s exciting to be able to offer this type of procedure to the patients of the Delaware Valley and beyond,” says Benny Weksler, MD, assistant professor, Department of Surgery. “Utilizing this technology not only reduces healing time and hospital stay, it also is significantly less painful, causes less scarring, reduces blood loss and in many cases, provides better clinical outcomes.”

Other surgeons who perform the procedure are Karen A. Chojnacki, MD, and Ernest L. (Gary) Rosato, MD.

A Better Alternative
During the procedure, the Jefferson surgeon uses the da Vinci system as part of the minimally invasive esophagectomy (the surgical removal of all or part of the esophagus). Robotic arms, with tiny cameras, are placed in the patient at the right chest. Four small incisions are used. 

Q&A: Prostate cancer treatments

5.14.2009 Jen Smith
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Adam P. Dicker, MD, earned his undergraduate degree from Columbia College, New York, his PhD in molecular pharmacology from Weill Graduate School of Medical Sciences of Cornell University and his MD from Weill Medical College of Cornell University. He completed his residency in radiation oncology at Memorial Sloan-Kettering Cancer Center. Dr. Dicker has conducted extensive research on prostate cancer therapies, is the author of Basic and Advanced Techniques in Prostate Brachytherapy, and is the only radiation oncologist on the Investigational Drug Steering Committee of the National Cancer Institute’s Cancer Therapy Evaluation Program. Here, Dr. Dicker answers a patient’s question about treatment options for prostate cancer.

Question: I’m a 65-year-old male recently diagnosed with early prostate cancer. I’m considering various types of radiation therapy – internal or external, involving either photons or protons. Which is best for me?

Answer: The field of radiation oncology has had significant technological advances over the past decade. Today, photons (x-rays) can be targeted at cancerous tissues in the prostate either externally or internally (see box below). Your urologist and radiation oncologist can advise you about which approach is right for you and potential side effects.

Susan G. Komen for the Cure awards grant to Jefferson's Kimmel Cancer Center

5.12.2009 Jen Smith
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Researchers from the Kimmel Cancer Center at Jefferson have been awarded a Susan G. Komen for the Cure Promise Grant of almost $6.7 million for five years for continued breast cancer research.

The project represents a multidisciplinary team of scientists from a consortium that also includes Walter Reed Army Medical Center and DecisionQ Inc. in Washington D.C., as well as the Windber Research Institute and MDR Global Inc. in Windber, Pa.

The principal investigator, Hallgeir Rui, MD, PhD, is a professor of Cancer Biology and Medical Oncology at Jefferson Medical College of Thomas Jefferson University. The co-principal investigator and leader of the clinical investigations associated with the project is Edith Mitchell, MD, medical oncologist and clinical professor of Medicine and Medical Oncology at Thomas Jefferson University and Associate Director of Diversity Programs for the Kimmel Cancer Center. The team will use the funds to investigate methods to optimize selection of patients for breast cancer treatment.

Read the full news release. You may also wish to visit the Jefferson Breast Care website.

Colon Cancer: Screening Options

5.07.2009 Jen Smith
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Colorectal cancer is the third most common cancer diagnosed among both men and women in the United States and the leading cause of cancer death.

Fortunately, it’s also easily prevented.

“Screening can help prevent colon cancer by finding and removing all polyps, or it can detect cancer early, when the cure rate is highest,” explains David M. Kastenberg, MD, associate professor of Medicine, Jefferson Medical College of Thomas Jefferson University.

Should you be screened?

Everyone should be screened beginning at age 50. If someone in your family has had polyps or colon cancer, you should have your first colonoscopy at age 40 or 10 before that relative was diagnosed – whichever occurs first.

Screening options
Guidelines from nationally recognized organizations recommend any of the following:

Q&A: Esophageal cancer

5.05.2009 Jen Smith
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Anthony Infantolino, MD, FACP, is a graduate of Robert Wood Johnson Medical School. He completed an internship and residency in internal medicine at Thomas Jefferson University Hospital and a Gastroenterology fellowship at The Graduate Hospital. Dr. Infantolino is Director of Endoscopic Ultrasound/Photodynamic Therapy at Thomas Jefferson University Hospital. A respected educator for nearly two decades, he is a sought-after lecturer and has been one of Philadelphia magazine’s “Top Doctors.” Here, Dr. Infantolino addresses a patient’s question about treatment of Barrett’s esophagus.

Question: I’ve had heartburn for years and just learned that I have Barrett’s esophagus. My doctor recommends treatment to eliminate the risk of esophageal cancer. How effective are these new treatments?

Answer: Barrett’s esophagus is a precancerous condition affecting the lining of the esophagus – the tube that carries food from the mouth to the stomach. Barrett’s esophagus results from chronic acid reflux, which can cause changes in the cells of the esophageal lining that may eventually become cancerous. Patients with Barrett’s esophagus have increased risk of developing esophageal cancer.